bivalirudin

Generic Name: bivalirudin (bye VAL i roo din)

Brand Names: Angiomax

What is bivalirudin?

Bivalirudin keeps the platelets in your blood from coagulating (clotting) to prevent unwanted blood clots that can occur with certain heart or blood vessel conditions.

Bivalirudin is used to prevent blood clots in people with severe chest pain or other conditions who are undergoing a procedure called angioplasty (to open blocked arteries).

Bivalirudin may also be used for purposes other than those listed in this medication guide.

What is the most important information I should know about bivalirudin?

Do not use this medication if you are allergic to bivalirudin, or if you have any major bleeding from a surgery, injury, or other medical trauma. Bivalirudin is not expected to be harmful to an unborn baby. However, aspirin is usually given with bivalirudin, and aspirin can cause bleeding when it is taken during the last 3 months of pregnancy. Aspirin can also cause side effects in a newborn baby.

Tell your doctor if you are pregnant or plan to become pregnant during treatment with bivalirudin and aspirin.

Before using bivalirudin, tell your doctor if you are allergic to any drugs, or if you have heart disease, kidney disease, or a bleeding or blood clotting disorder such as hemophilia.

Tell your doctor if you are using or receiving blood thinners or any other medications used to prevent blood clots, such as alteplase (Activase), anistreplase (Eminase), clopidogrel (Plavix), dipyridamole (Persantine), streptokinase (Kabikinase, Streptase), ticlopidine (Ticlid), or urokinase (Abbokinase).

Because bivalirudin keeps your blood from coagulating (clotting) to prevent unwanted blood clots, it can also make it easier for you to bleed, even from a minor injury. Contact your doctor or seek emergency medical attention if you have bleeding that will not stop.

What should I discuss with my health care provider before taking bivalirudin?

Do not use this medication if you are allergic to bivalirudin, or if you have any major bleeding from a surgery, injury, or other medical trauma.

Before using bivalirudin, tell your doctor if you are allergic to any drugs, or if you have:

• 
  

  heart disease;

  
  


• 
  

  kidney disease; or

  
  


• 
  

  a bleeding or blood clotting disorder (such as hemophilia).

  
  

If you have any of these conditions, you may not be able to use bivalirudin, or you may need dosage adjustments or special tests during treatment.

FDA pregnancy category B. This medication is not expected to be harmful to an unborn baby. However, aspirin is usually given with bivalirudin, and aspirin can cause bleeding when it is taken during the last 3 months of pregnancy. Aspirin can also cause side effects in a newborn baby.

Tell your doctor if you are pregnant or plan to become pregnant during treatment with bivalirudin and aspirin.

It is not known whether bivalirudin passes into breast milk or if it could harm a nursing baby. Do not use this medication without telling your doctor if you are breast-feeding a baby.

How should I take bivalirudin?

Bivalirudin is given as an injection through a needle placed into a vein. You will receive this injection during your angioplasty procedure in a clinic or hospital setting. The medicine must be given throughout the entire procedure.

Bivalirudin is usually given together with aspirin.

Because bivalirudin keeps your blood from coagulating (clotting) to prevent unwanted blood clots, it can also make it easier for you to bleed, even from a minor injury. Contact your doctor or seek emergency medical attention if you have bleeding that will not stop.

See also: Bivalirudin dosage (in more detail)

What happens if I miss a dose?

Since bivalirudin is usually given in a hospital or clinic setting as needed, it is not likely that you will miss a dose.

What happens if I overdose?

Seek emergency medical attention if you think you have used too much of this medicine.

Symptoms of a bivalirudin overdose are not known.

What should I avoid while taking bivalirudin?

Bivalirudin lowers blood cells that help your blood clot. This can make it easier for you to bruise or bleed from an injury or minor cut. Avoid activities that increase your risk of a bruising or bleeding injury. Use extra caution to avoid cuts when brushing your teeth or shaving.

Avoid drinking alcohol while taking bivaluridin. Alcohol may increase your risk of bleeding in your stomach or intestines.

Bivalirudin side effects

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat. Call your doctor at once if you have any of these serious side effects:

• 
  

  sudden numbness or weakness, especially on one side of the body;

  
  


• 
  

  sudden headache, confusion, problems with vision, speech, or balance;

  
  


• 
  

  pain or swelling in one or both legs;

  
  


• 
  

  any bleeding that will not stop;

  
  


• 
  

  black, bloody, or tarry stools;

  
  


• 
  

  coughing up blood or vomit that looks like coffee grounds;

  
  


• 
  

  slow heart rate;

  
  


• 
  

  increased blood pressure (severe headache, blurred vision, trouble concentrating, chest pain, numbness, seizure);

  
  


• 
  

  decreased blood pressure (feeling light-headed or fainting); or

  
  


• 
  

  urinating less than usual or not at all.

  
  

Less serious side effects are more likely to occur, such as:

• 
  

  pain in your back or pelvis;

  
  


• 
  

  nausea, vomiting, stomach pain or upset;

  
  


• 
  

  feeling restless or nervous;

  
  


• 
  

  headache;

  
  


• 
  

  fever;

  
  


• 
  

  sleep problems (insomnia);

  
  


• 
  

  pain, bleeding, or irritation where the injection was given.

  
  

Side effects other than those listed here may also occur. Talk to your doctor about any side effect that seems unusual or that is especially bothersome. You may report side effects to FDA at 1-800-FDA-1088.

Bivalirudin Dosing Information

Usual Adult Dose for Angina Pectoris:

Initial: 0.75 mg/kg administered as an intravenous bolus dose, followed by 1.75 mg/kg/hour for the duration of the PCI procedure.

Five minutes after the bolus dose, an ACT should be performed and an additional bolus of 0.3 mg/kg should be given if needed. Administration of a glycoprotein IIb/IIIa inhibitor should be considered in the event that any of the following conditions are present: decreased TIMI flow (0 to 2) or slow reflow; dissection with decreased flow; new or suspected thrombus; persistent residual stenosis; distal embolization; unplanned stent; suboptimal stenting; side branch closure; abrupt closure; clinical instability; and prolonged ischemia.

The recommended dose of bivalirudin in patients with HIT/HITTS undergoing PCI is an IV bolus dose of 0.75 mg/kg, followed by a continuous infusion at a rate of 1.75 mg/kg/hour for the duration of the procedure.

Continuation of the infusion for up to 4 hours post procedure is optional. After 4 hours, an additional IV infusion may be initiated at a rate of 0.2 mg/kg/hour for up to 20 hours if needed.

Bivalirudin is intended for use with aspirin (300 mg to 325 mg daily), and has been studied only in patients receiving concomitant aspirin.

Usual Adult Dose for Percutaneous Coronary Intervention:

Initial: 0.75 mg/kg administered as an intravenous bolus dose, followed by 1.75 mg/kg/hour for the duration of the PCI procedure.

Five minutes after the bolus dose, an ACT should be performed and an additional bolus of 0.3 mg/kg should be given if needed. Administration of a glycoprotein IIb/IIIa inhibitor should be considered in the event that any of the following conditions are present: decreased TIMI flow (0 to 2) or slow reflow; dissection with decreased flow; new or suspected thrombus; persistent residual stenosis; distal embolization; unplanned stent; suboptimal stenting; side branch closure; abrupt closure; clinical instability; and prolonged ischemia.

The recommended dose of bivalirudin in patients with HIT/HITTS undergoing PCI is an IV bolus dose of 0.75 mg/kg, followed by a continuous infusion at a rate of 1.75 mg/kg/hour for the duration of the procedure.

Continuation of the infusion for up to 4 hours post procedure is optional. After 4 hours, an additional IV infusion may be initiated at a rate of 0.2 mg/kg/hour for up to 20 hours if needed.

Bivalirudin is intended for use with aspirin (300 mg to 325 mg daily), and has been studied only in patients receiving concomitant aspirin.

What other drugs will affect bivalirudin?

Before receiving bivalirudin, tell your doctor if you are using or receiving any of the following drugs:

• 
  

  a blood thinner such as warfarin (Coumadin), heparin, ardeparin (Normiflo), dalteparin (Fragmin), danaparoid (Orgaran), enoxaparin (Lovenox), or tinzaparin (Innohep); or

  
  


• 
  

  any other medications used to prevent blood clots, such as alteplase (Activase), anistreplase (Eminase), clopidogrel (Plavix), dipyridamole (Persantine), streptokinase (Kabikinase, Streptase), ticlopidine (Ticlid), or urokinase (Abbokinase).

  
  

If you are using any of these drugs, you may not be able to use bivalirudin, or you may need dosage adjustments or special tests during treatment.

There may be other drugs not listed that can affect bivalirudin. Tell your doctor about all the prescription and over-the-counter medications you use. This includes vitamins, minerals, herbal products, and drugs prescribed by other doctors. Do not start using a new medication without telling your doctor.

More bivalirudin resources

• Bivalirudin Side Effects (in more detail)
• Bivalirudin Dosage
• Bivalirudin Use in Pregnancy & Breastfeeding
• Bivalirudin Drug Interactions
• Bivalirudin Support Group
• 0 Reviews for Bivalirudin - Add your own review/rating

• bivalirudin Intravenous Advanced Consumer (Micromedex) - Includes Dosage Information


• Bivalirudin Professional Patient Advice (Wolters Kluwer)


• Bivalirudin Monograph (AHFS DI)


• Bivalirudin MedFacts Consumer Leaflet (Wolters Kluwer)


• Angiomax Prescribing Information (FDA)

Compare bivalirudin with other medications

• Angina
• Percutaneous Coronary Intervention

Where can I get more information?

• Your pharmacist has information about bivalirudin written for health professionals that you may read.

See also: bivalirudin side effects (in more detail)

Pinden

Pinden may be available in the countries listed below.

Ingredient matches for Pinden

Pindolol

Pindolol is reported as an ingredient of Pinden in the following countries:

• Israel

International Drug Name Search

Bisoprolol/Hydrochlorothiazide

Pronunciation: BIS-oh-PROE-lol/HYE-droe-KLOR-oh-THYE-a-zide
Generic Name: Bisoprolol/Hydrochlorothiazide
Brand Name: Ziac

Bisoprolol/Hydrochlorothiazide is used for:

Treating high blood pressure.

Bisoprolol/Hydrochlorothiazide is a beta-blocker and diuretic combination. The beta-blocker works by slowing down the heartbeat, helping the heart beat more regularly, and reducing the amount of work the heart has to do. The diuretic increases the elimination of excess fluid, which helps to decrease blood pressure.

Do NOT use Bisoprolol/Hydrochlorothiazide if:

• you are allergic to any ingredient in Bisoprolol/Hydrochlorothiazide or to a sulfonamide medicine (eg, sulfamethoxazole, probenecid, glyburide)


• you have uncontrolled heart failure, heart block, a very slow heart rate, or shock caused by serious heart problems


• you are unable to urinate


• you are taking another beta-blocker (eg, propranolol), dofetilide, or mibefradil

Contact your doctor or health care provider right away if any of these apply to you.

Before using Bisoprolol/Hydrochlorothiazide:

Some medical conditions may interact with Bisoprolol/Hydrochlorothiazide. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

• if you are pregnant, planning to become pregnant, or are breast-feeding


• if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement


• if you have allergies to medicines, foods, or other substances


• if you have asthma, bronchitis, lung disease (eg, chronic obstructive pulmonary disease [COPD]), diabetes, gout, an overactive thyroid, low blood levels of potassium or sodium, blood vessel or circulation problems, an adrenal gland tumor (pheochromocytoma), lupus, liver disease, or kidney problems


• if you have low blood pressure or a history of chest pain or angina, heart attack, slow or irregular heartbeat, or other heart problems (eg, heart failure)


• if you will be having surgery or receiving anesthesia


• if you have recently had a certain type of nerve surgery (sympathectomy)

Some MEDICINES MAY INTERACT with Bisoprolol/Hydrochlorothiazide. Tell your health care provider if you are taking any other medicines, especially any of the following:

• Antiarrhythmics (eg, disopyramide, flecainide), calcium channel blockers (eg, verapamil, diltiazem), cimetidine, digoxin, fingolimod, or other medicines for blood pressure because side effects, such as slow or irregular heart beat or low blood pressure, may occur


• Angiotensin-converting enzyme (ACE) inhibitors (eg, enalapril), barbiturates (eg, phenobarbital), diazoxide, mefloquine, mibefradil, narcotics (eg, codeine), or nifedipine because the actions and side effects of Bisoprolol/Hydrochlorothiazide and these medicines may be increased


• Adrenocorticotropic hormone (ACTH), other beta-blockers (eg, propranolol), corticosteroids (eg, prednisone), guanethidine, or reserpine because they may increase the risk of Bisoprolol/Hydrochlorothiazide's side effects


• Cholestyramine, colestipol, nonsteroidal anti-inflammatory drugs (NSAIDs) (eg, ibuprofen), or rifamycins (eg, rifampin) because they may decrease Bisoprolol/Hydrochlorothiazide's effectiveness


• Allopurinol, amantadine, dofetilide, insulin or other medicines for diabetes (eg, glyburide), ketanserin, or lithium because their actions and the risk of their side effects may be increased


• Clonidine because stopping it or Bisoprolol/Hydrochlorothiazide suddenly can lead to a rapid increase in blood pressure

This may not be a complete list of all interactions that may occur. Ask your health care provider if Bisoprolol/Hydrochlorothiazide may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use Bisoprolol/Hydrochlorothiazide:

Use Bisoprolol/Hydrochlorothiazide as directed by your doctor. Check the label on the medicine for exact dosing instructions.

• Take Bisoprolol/Hydrochlorothiazide by mouth with or without food.


• If you also take cholestyramine or colestipol, ask your doctor or pharmacist how to take it with Bisoprolol/Hydrochlorothiazide.


• Bisoprolol/Hydrochlorothiazide may increase the amount of urine or cause you to urinate more often when you first start taking it. To keep this from disturbing your sleep, try to take your dose before 6 pm.


• Take Bisoprolol/Hydrochlorothiazide on a regular schedule to get the most benefit from it.


• Continue to take Bisoprolol/Hydrochlorothiazide even if you feel well. Do not miss any doses.


• If you miss a dose of Bisoprolol/Hydrochlorothiazide, take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once.

Ask your health care provider any questions you may have about how to use Bisoprolol/Hydrochlorothiazide.

Important safety information:

• Bisoprolol/Hydrochlorothiazide may cause dizziness or light-headedness. These effects may be worse if you take it with alcohol or certain medicines. Use Bisoprolol/Hydrochlorothiazide with caution. Do not drive or perform other possibly unsafe tasks until you know how you react to it.


• Bisoprolol/Hydrochlorothiazide may cause dizziness, light-headedness, or fainting; alcohol, hot weather, exercise, or fever may increase these effects. To prevent them, sit up or stand slowly, especially in the morning. Sit or lie down at the first sign of any of these effects.


• Drink plenty of fluids while taking Bisoprolol/Hydrochlorothiazide and avoid engaging in activities that cause excessive sweating. Dehydration, excessive sweating, vomiting, or diarrhea may lead to a fall in blood pressure. Contact your health care provider at once if any of these occur.


• Bisoprolol/Hydrochlorothiazide may decrease the amount of potassium in your body. If your doctor has also prescribed a potassium supplement for you, follow the dosing directions carefully. Check with your doctor before taking additional potassium on your own or including foods high in potassium (eg, bananas, orange juice) in your diet.


• Patients who take medicine for high blood pressure often feel tired or run down for a few weeks after starting treatment. Be sure to take your medicine even if you may not feel "normal." Tell your doctor if you develop any new symptoms.


• Bisoprolol/Hydrochlorothiazide contains a sulfonamide called hydrochlorothiazide, which can cause certain eye problems (myopia, angle-closure glaucoma). Your risk may be increased if you are allergic to sulfonamide medicines (eg, sulfamethoxazole) or to penicillin antibiotics (eg, amoxicillin). Untreated angle-closure glaucoma can lead to permanent vision loss. If these eye problems occur, symptoms usually occur within hours to weeks of starting Bisoprolol/Hydrochlorothiazide. Contact your doctor immediately if you experience symptoms such as vision changes (eg, decreased vision clearness) or eye pain.


• Do not suddenly stop taking Bisoprolol/Hydrochlorothiazide. Sharp chest pain, irregular heartbeat, and sometimes heart attack may occur if you suddenly stop taking Bisoprolol/Hydrochlorothiazide. The risk may be greater if you have certain types of heart disease. Your doctor should slowly lower your dose. When stopping treatment with Bisoprolol/Hydrochlorothiazide, your doctor will need to slowly decrease your dose over a period of 1 to 2 weeks and will watch you closely for side effects. If new or worsened chest pain or other heart problems occur, contact your doctor right away. You may need to start taking Bisoprolol/Hydrochlorothiazide again. Because heart artery disease is common and you may not know you have it, it may be safer not to stop Bisoprolol/Hydrochlorothiazide quickly even if you are only being treated for high blood pressure.


• Bisoprolol/Hydrochlorothiazide may cause you to become sunburned more easily. Avoid the sun, sunlamps, or tanning booths until you know how you react to Bisoprolol/Hydrochlorothiazide. Use a sunscreen or wear protective clothing if you must be outside for more than a short time.


• Tell your doctor or dentist that you take Bisoprolol/Hydrochlorothiazide before you receive any medical or dental care, emergency care, or surgery.


• If you have high blood pressure, do not use nonprescription products that contain stimulants. These products may include diet pills or cold medicines. Contact your doctor if you have any questions or concerns.


• Diabetes patients - Bisoprolol/Hydrochlorothiazide may hide signs of low blood sugar, such as a rapid heartbeat. Be sure to watch for other signs of low blood sugar. Low blood sugar may make you anxious, sweaty, weak, dizzy, drowsy, or faint. It may also make your vision change; give you a headache, chills, or tremors; or make you more hungry. Check blood sugar levels closely. Ask your doctor before you change the dose of your diabetes medicine.


• If you have a history of any severe allergic reaction, talk with your doctor. You may be at risk of an even more severe allergic reaction if you come into contact with the substance that caused your allergy. Some medicines used to treat severe allergies may also not work as well while you are taking Bisoprolol/Hydrochlorothiazide.


• Bisoprolol/Hydrochlorothiazide may interfere with certain lab tests, including parathyroid function. Be sure your doctor and lab personnel know you are taking Bisoprolol/Hydrochlorothiazide.


• Lab tests, including blood pressure, heart rate, and blood electrolytes, may be performed while you use Bisoprolol/Hydrochlorothiazide. These tests may be used to monitor your condition or check for side effects. Be sure to keep all doctor and lab appointments.


• Use Bisoprolol/Hydrochlorothiazide with caution in the ELDERLY; they may be more sensitive to its effects.


• Bisoprolol/Hydrochlorothiazide should be used with extreme caution in CHILDREN; safety and effectiveness in children have not been confirmed.


• PREGNANCY and BREAST-FEEDING: It is not known if Bisoprolol/Hydrochlorothiazide can cause harm to the fetus. If you become pregnant, contact your doctor. You will need to discuss the benefits and risks of using Bisoprolol/Hydrochlorothiazide while you are pregnant. Bisoprolol/Hydrochlorothiazide is found in breast milk. Do not breast-feed while taking Bisoprolol/Hydrochlorothiazide.

Possible side effects of Bisoprolol/Hydrochlorothiazide:

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Diarrhea; dizziness; headache; light-headedness; tiredness.

Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue; unusual hoarseness); chest pain; chills, fever, or sore throat; cold hands or feet; decreased urination; drowsiness; dry mouth or eyes; eye pain; fainting; mood or mental changes (eg, anxiety, decreased concentration, decreased memory, depression, hallucinations); muscle pain, cramps, or weakness; nausea; red, swollen, blistered, or peeling skin; restlessness; ringing in the ears or decreased hearing; severe or persistent dizziness or light-headedness; severe or persistent stomach pain; shortness of breath; slow, fast, or irregular heartbeat; sudden, unexplained weight gain; swelling of the hands, ankles, or feet; symptoms of low blood sodium levels (eg, confusion, seizures, sluggishness); unusual bruising or bleeding; unusual thirst, weakness, or fatigue; vision changes (eg, blurred vision, decreased vision clearness); vomiting; wheezing; yellowing of the skin or eyes.

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. To report side effects to the appropriate agency, please read the Guide to Reporting Problems to FDA.

See also: Bisoprolol/Hydrochlorothiazide side effects (in more detail)

If OVERDOSE is suspected:

Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center, or emergency room immediately. Symptoms may include fainting; loss of consciousness; severe dizziness or light-headedness; slow heart rate; symptoms of blood electrolyte problems (eg, confusion; irregular heartbeat; mental or mood changes; muscle pain, weakness, or cramping; seizures; sluggishness); symptoms of dehydration (eg, drowsiness; dry mouth or eyes; fast heartbeat; nausea or vomiting; unusual thirst, weakness, or fatigue); trouble breathing.

Proper storage of Bisoprolol/Hydrochlorothiazide:

Store Bisoprolol/Hydrochlorothiazide at room temperature, between 68 and 77 degrees F (20 and 25 degrees C). Store away from heat, moisture, and light. Do not store in the bathroom. Keep Bisoprolol/Hydrochlorothiazide out of the reach of children and away from pets.

General information:

• If you have any questions about Bisoprolol/Hydrochlorothiazide, please talk with your doctor, pharmacist, or other health care provider.


• Bisoprolol/Hydrochlorothiazide is to be used only by the patient for whom it is prescribed. Do not share it with other people.


• If your symptoms do not improve or if they become worse, check with your doctor.


• Check with your pharmacist about how to dispose of unused medicine.

This information is a summary only. It does not contain all information about Bisoprolol/Hydrochlorothiazide. If you have questions about the medicine you are taking or would like more information, check with your doctor, pharmacist, or other health care provider.

Issue Date: February 1, 2012

Database Edition 12.1.1.002

Copyright © 2012 Wolters Kluwer Health, Inc.

More Bisoprolol/Hydrochlorothiazide resources

• Bisoprolol/Hydrochlorothiazide Side Effects (in more detail)
• Bisoprolol/Hydrochlorothiazide Use in Pregnancy & Breastfeeding
• Drug Images
• Bisoprolol/Hydrochlorothiazide Drug Interactions
• Bisoprolol/Hydrochlorothiazide Support Group
• 11 Reviews for Bisoprolol/Hydrochlorothiazide - Add your own review/rating

Compare Bisoprolol/Hydrochlorothiazide with other medications

• High Blood Pressure

Ismacrol

Ismacrol may be available in the countries listed below.

Ingredient matches for Ismacrol

Spiramycin

Spiramycin is reported as an ingredient of Ismacrol in the following countries:

• Indonesia

International Drug Name Search

Butrans transdermal

Generic Name: buprenorphine (transdermal) (BUE pre NOR feen)

Brand Names: Butrans

What is this drug?

Buprenorphine is a narcotic (opioid) pain medicine.

Buprenorphine transdermal (skin patch) is used to treat moderate to severe chronic pain when treatment is needed around the clock.

Buprenorphine is not for treating pain just after surgery, or for treating occasional short-term pain.

Buprenorphine transdermal may also be used for purposes not listed in this medication guide.

What is the most important information I should know about this drug?

You should not use buprenorphine if you are allergic to it, or if you have a severe breathing disorder such as asthma, or a bowel obstruction called paralytic ileus.

Never wear more than 1 buprenorphine skin patch at a time unless your doctor has told you to.

Do not expose the skin patch to heat while you are wearing it. Heat can increase the amount of drug you absorb through your skin and may cause harmful effects.

Call your doctor at once if you have weak or shallow breathing, snoring that is new or unusual, slow heart rate, confusion, severe dizziness, seizure, or feeling like you might pass out.

Avoid letting another person handle your buprenorphine skin patches. Keep both used and unused patches out of the reach of children or pets. The amount of buprenorphine in a used skin patch could be fatal to a child or pet who accidentally sucks or chews on it. Seek emergency medical attention if this happens. Do not stop using buprenorphine suddenly, or you could have unpleasant withdrawal symptoms. Ask your doctor how to avoid withdrawal symptoms when you stop using buprenorphine.

What should I discuss with my health care provider before using this drug?

You should not use buprenorphine if you are allergic to it, or if you have:

• 
  

  asthma or severe breathing disorder; or

  
  


• 
  

  a bowel obstruction called paralytic ileus.

  
  

Do not use buprenorphine if you have used an MAO inhibitor such as furazolidone (Furoxone), isocarboxazid (Marplan), phenelzine (Nardil), rasagiline (Azilect), selegiline (Eldepryl, Emsam, Zelapar), or tranylcypromine (Parnate) in the last 14 days. Serious, life threatening side effects can occur if you use buprenorphine before the MAO inhibitor has cleared from your body.

To make sure you can safely use buprenorphine, tell your doctor if you have any of these other conditions:

• 
  

  COPD (chronic obstructive pulmonary disease), sleep apnea, or other breathing disorders;

  
  


• 
  

  a personal or family history of "Long QT syndrome":

  
  


• 
  

  hepatitis B or C;

  
  


• 
  

  liver or kidney disease;

  
  


• 
  

  a thyroid disorder;

  
  


• 
  

  gallbladder disease;

  
  


• 
  

  curvature of the spine;

  
  


• 
  

  a history of head injury or brain tumor;

  
  


• 
  

  epilepsy or other seizure disorder;

  
  


• 
  

  low blood pressure;

  
  


• 
  

  Addison's disease or other adrenal gland disorders;

  
  


• 
  

  enlarged prostate, urination problems;

  
  


• 
  

  depression or other mental illness; or

  
  


• 
  

  a history of drug or alcohol addiction.

  
  

Buprenorphine may be habit-forming and should be used only by the person it was prescribed for. Never share buprenorphine with another person, especially someone with a history of drug abuse or addiction. Keep the medication in a place where others cannot get to it. FDA pregnancy category C. It is not known whether buprenorphine will harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant while using this medication. Buprenorphine can pass into breast milk and may harm a nursing baby. You should not breast-feed while you are using buprenorphine.

Your dose needs may be different if you have recently used an opioid pain medicine and your body is tolerant to it. Opioids include Tylenol #3, Lortab, Vicodin, OxyContin, Percocet, Darvocet, Actiq, morphine, and many others. Talk with your doctor if you are not sure you are opioid-tolerant.

How should I use this drug?

Use exactly as prescribed. Never use buprenorphine in larger amounts, or for longer than recommended by your doctor. Follow the directions on your prescription label. Tell your doctor if the medicine seems to stop working as well in relieving your pain.

This medication comes with patient instructions for safe and effective use. Follow these directions carefully. Ask your doctor or pharmacist if you have any questions.

If you are switching to buprenorphine transdermal from another narcotic pain medicine, you may need to slowly stop using the other medicine. Follow your doctor's instructions.

Apply the skin patch only to clean, dry skin. Use only clear water to wash the skin before you apply a skin patch. Soaps or other chemicals could increase the amount of buprenorphine your skin absorbs.

Apply the patch to a flat and hairless area of the chest, back, side, or outer side of your upper arm. Wear the patch around the clock for 7 days. Never wear more than 1 buprenorphine skin patch at a time unless your doctor has told you to.

Do not use soaps or other chemicals could increase the amount of buprenorphine your skin absorbs.

Do not use a buprenorphine transdermal skin patch if it has been cut or damaged.

After removing a skin patch fold it in half, sticky side in, and flush the patch down the toilet or use the Patch-Disposal Unit provided with this medication. Apply a new patch to a different skin area on the chest, back, side, or upper arm. Do not use the same skin area twice in a row.

Never share this medication with another person, even if they have the same symptoms you have. Ask your doctor how to avoid withdrawal symptoms when you stop using buprenorphine. Keep both used and unused buprenorphine skin patches out of the reach of children or pets. The amount of buprenorphine in a used skin patch could be fatal to a child or pet who accidentally sucks or chews on the patch. Seek emergency medical attention if this happens.

Keep track of how many skin patches have been used from each new package of this medicine. Buprenorphine is a drug of abuse and you should be aware if any person in the household is using this medicine improperly or without a prescription.

Store at room temperature. Keep each patch in its foil pouch until you are ready to use it.

What happens if I miss a dose?

If you forget to change a patch on your scheduled day, remove the patch and apply a new one as soon as you remember. Do not wear extra patches to make up a missed dose.

What happens if I overdose?

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. The amount of buprenorphine in a used or unused skin patch can be fatal to a child who accidentally sucks or chews on the patch.

Overdose symptoms may include extreme drowsiness, weak or limp feeling, weak pulse, cold and clammy skin, fainting, shallow breathing, snoring, or breathing that stops.

What should I avoid while using this drug?

Do not drink alcohol or you may have serious, life-threatening side effects. Buprenorphine may impair your thinking or reactions. Be careful if you drive or do anything that requires you to be alert. Avoid getting up too fast from a sitting or lying position, or you may feel dizzy. Get up slowly and steady yourself to prevent a fall. Do not expose the skin patch to heat while you are wearing it. This includes a hot tub, heating pad, electric blanket, sauna, heated water bed, or a hot bath. Avoid exposure to sunlight or tanning beds. Heat can increase the amount of drug you absorb through your skin and may cause harmful effects. Avoid letting another person handle your buprenorphine skin patches. If the sticky side of a skin patch comes into contact with another person, wash the skin with clear water and seek medical care at once.

This drug side effects

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat. Stop using buprenorphine and call your doctor at once if you have a serious side effect such as:

• 
  

  slow heart rate, weak or shallow breathing, deep sighs, snoring that is new or unusual;

  
  


• 
  

  confusion, severe dizziness, feeling like you might pass out;

  
  


• 
  

  blisters, swelling, or severe irritation where the patch was worn;

  
  


• 
  

  seizure (convulsions); or

  
  


• 
  

  nausea, upper stomach pain, loss of appetite, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes).

  
  

Less serious side effects may include:

• 
  

  headache;

  
  


• 
  

  vomiting, dry mouth, upset stomach, constipation;

  
  


• 
  

  mild dizziness or drowsiness; or

  
  


• 
  

  redness, itching, or mild skin rash where the patch was worn.

  
  

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What other drugs will affect this drug?

Tell your doctor if you regularly use other medicines that can make you sleepy or slow your breathing (such as cold or allergy medicine, sedatives, anti-nausea medicine, other narcotic pain medicines, sleeping pills, muscle relaxers, heart rhythm medications, and medicine for seizures, depression, or anxiety). They can add to the side effects of buprenorphine and dangerous side effects may result.

• 
  

  dexamethasone (Decadron, Hexadrol);

  
  


• 
  

  St. John's wort;

  
  


• 
  

  rifabutin (Mycobutin), rifampin (Rifadin, Rifater, Rifamate), or rifapentine (Priftin);

  
  


• 
  

  phenobarbital (Solfoton) or other barbiturates;

  
  


• 
  

  diazepam (Valium) or similar medicines such as alprazolam (Xanax), lorazepam (Ativan), clorazepate (Tranxene), and others;

  
  


• 
  

  a heart rhythm medication such as amiodarone (Cordarone, Pacerone), disopyramide (Norpace), dofetilide (Tikosyn), flecaininde (Tambocor), procainamide (Pronestyl), propafenone, (Rythmol), quinidine (Quin-G), sotalol (Betapace), and others;

  
  


• 
  

  HIV medication such as efavirenz (Sustiva), etravirine (Intelence), nevirapine (Viramune), or ritonavir (Kaletra, Norvir); or

  
  


• 
  

  seizure medication such as carbamazepine (Carbatrol, Tegretol), felbamate (Felbatol), oxcarbazepine (Trileptal), phenytoin (Dilantin), or primidone (Mysoline).

  
  

This list is not complete and other drugs may interact with buprenorphine. Tell your doctor about all medications you use. This includes prescription, over-the-counter, vitamin, and herbal products. Do not start a new medication without telling your doctor.

More Butrans resources

• Butrans Side Effects (in more detail)
• Butrans Use in Pregnancy & Breastfeeding
• Butrans Drug Interactions
• Butrans Support Group
• 29 Reviews for Butrans - Add your own review/rating

Compare Butrans with other medications

• Pain

Where can I get more information?

• Your pharmacist can provide more information about buprenorphine.

See also: Butrans side effects (in more detail)

Baridium

Generic Name: phenazopyridine (Oral route)

fen-ay-zoe-PIR-i-deen

Commonly used brand name(s)

In the U.S.

• Azo-Gesic


• Azo-Septic


• Azo-Standard


• Baridium


• Phenazo 95


• Prodium


• Pyridiate


• Pyridium


• RE-Azo


• Urinary Pain Relief


• Uristat


• UTI Relief

Available Dosage Forms:

• Tablet


• Kit

Therapeutic Class: Analgesic

Uses For Baridium

Phenazopyridine is used to relieve the pain, burning, and discomfort caused by infection or irritation of the urinary tract. It is not an antibiotic and will not cure the infection itself.

In the U.S., phenazopyridine is available without a prescription.

Before Using Baridium

In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For this medicine, the following should be considered:

Allergies

Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.

Pediatric

Although there is no specific information comparing use of phenazopyridine in children with use in other age groups, it is not expected to cause different side effects or problems in children than it does in adults.

Geriatric

Many medicines have not been studied specifically in older people. Therefore, it may not be known whether they work exactly the same way they do in younger adults. Although there is no specific information comparing use of phenazopyridine in the elderly with use in other age groups, this medicine is not expected to cause different side effects or problems in older people than it does in younger adults.

Pregnancy

	Pregnancy Category	Explanation
All Trimesters	B	Animal studies have revealed no evidence of harm to the fetus, however, there are no adequate studies in pregnant women OR animal studies have shown an adverse effect, but adequate studies in pregnant women have failed to demonstrate a risk to the fetus.

Breast Feeding

There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding.

Interactions with Medicines

Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. Tell your healthcare professional if you are taking any other prescription or nonprescription (over-the-counter [OTC]) medicine.

Interactions with Food/Tobacco/Alcohol

Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. Discuss with your healthcare professional the use of your medicine with food, alcohol, or tobacco.

Other Medical Problems

The presence of other medical problems may affect the use of this medicine. Make sure you tell your doctor if you have any other medical problems, especially:

• Glucose-6-phosphate dehydrogenase (G6PD) deficiency or


• Hepatitis or


• Kidney disease—The chance of side effects may be increased.

Proper Use of phenazopyridine

This section provides information on the proper use of a number of products that contain phenazopyridine. It may not be specific to Baridium. Please read with care.

This medicine is best taken with food or after eating a meal or a snack to lessen stomach upset.

Do not use any leftover medicine for future urinary tract problems without first checking with your doctor. An infection may require additional medicine.

Dosing

The dose of this medicine will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of this medicine. If your dose is different, do not change it unless your doctor tells you to do so.

The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.

• For oral dosage form (tablets):
  
  • For relieving pain, burning, and discomfort in the urinary tract:
    
    • Adults and teenagers—200 milligrams (mg) three times a day.
    
    
    • Children—The dose is based on body weight and must be determined by your doctor. The usual dose is 4 mg per kilogram (kg) (about 1.8 mg per pound) of body weight three times a day.
    
    
  
  

Missed Dose

If you miss a dose of this medicine, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not double doses.

Storage

Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.

Keep out of the reach of children.

Do not keep outdated medicine or medicine no longer needed.

Precautions While Using Baridium

Check with your doctor if symptoms such as bloody urine, difficult or painful urination, frequent urge to urinate, or sudden decrease in the amount of urine appear or become worse while you are taking this medicine .

Phenazopyridine causes the urine to turn reddish orange . This is to be expected while you are using it. This effect is harmless and will go away after you stop taking the medicine. Also, the medicine may stain clothing.

For patients who wear soft contact lenses:

• It is best not to wear soft contact lenses while being treated with this medicine. Phenazopyridine may cause discoloration or staining of contact lenses. It may not be possible to remove the stain.

For diabetic patients:

• This medicine may cause false test results with urine sugar tests and urine ketone tests. If you have any questions about this, check with your health care professional, especially if your diabetes is not well controlled.

Before you have any medical tests, tell the person in charge that you are taking this medicine. The results of some tests may be affected by this medicine.

Baridium Side Effects

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor as soon as possible if any of the following side effects occur:

Rare

• Blue or blue-purple color of skin


• fever and confusion


• shortness of breath, tightness in chest, wheezing, or troubled breathing


• skin rash


• sudden decrease in the amount of urine


• swelling of face, fingers, feet, and/or lower legs


• unusual tiredness or weakness


• weight gain


• yellow eyes or skin

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

Less common or rare

• Dizziness


• headache


• indigestion


• itching of the skin


• stomach cramps or pain

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

See also: Baridium side effects (in more detail)

The information contained in the Thomson Reuters Micromedex products as delivered by Drugs.com is intended as an educational aid only. It is not intended as medical advice for individual conditions or treatment. It is not a substitute for a medical exam, nor does it replace the need for services provided by medical professionals. Talk to your doctor, nurse or pharmacist before taking any prescription or over the counter drugs (including any herbal medicines or supplements) or following any treatment or regimen. Only your doctor, nurse, or pharmacist can provide you with advice on what is safe and effective for you.

The use of the Thomson Reuters Healthcare products is at your sole risk. These products are provided "AS IS" and "as available" for use, without warranties of any kind, either express or implied. Thomson Reuters Healthcare and Drugs.com make no representation or warranty as to the accuracy, reliability, timeliness, usefulness or completeness of any of the information contained in the products. Additionally, THOMSON REUTERS HEALTHCARE MAKES NO REPRESENTATION OR WARRANTIES AS TO THE OPINIONS OR OTHER SERVICE OR DATA YOU MAY ACCESS, DOWNLOAD OR USE AS A RESULT OF USE OF THE THOMSON REUTERS HEALTHCARE PRODUCTS. ALL IMPLIED WARRANTIES OF MERCHANTABILITY AND FITNESS FOR A PARTICULAR PURPOSE OR USE ARE HEREBY EXCLUDED. Thomson Reuters Healthcare does not assume any responsibility or risk for your use of the Thomson Reuters Healthcare products.

More Baridium resources

• Baridium Side Effects (in more detail)
• Baridium Use in Pregnancy & Breastfeeding
• Baridium Drug Interactions
• Baridium Support Group
• 0 Reviews for Baridium - Add your own review/rating

• Azo-Gesic MedFacts Consumer Leaflet (Wolters Kluwer)


• Phenazopyridine Hydrochloride Monograph (AHFS DI)


• Pyridium Consumer Overview

Compare Baridium with other medications

• Dysuria
• Interstitial Cystitis

Cisordinol Acutard

Cisordinol-Acutard may be available in the countries listed below.

Ingredient matches for Cisordinol-Acutard

Zuclopenthixol

Zuclopenthixol acetate (a derivative of Zuclopenthixol) is reported as an ingredient of Cisordinol-Acutard in the following countries:

• Austria


• Chile


• Czech Republic


• Denmark


• Finland


• Hungary


• Iceland


• Lithuania


• Norway


• Peru


• Slovakia


• Sweden

International Drug Name Search

Ciprofloxacino

Ciprofloxacino may be available in the countries listed below.

Ingredient matches for Ciprofloxacino

Ciprofloxacin

Ciprofloxacin is reported as an ingredient of Ciprofloxacino in the following countries:

• Chile


• Colombia


• Ecuador


• Peru

Ciprofloxacin hydrochloride (a derivative of Ciprofloxacin) is reported as an ingredient of Ciprofloxacino in the following countries:

• Chile

Ciprofloxacin lactate (a derivative of Ciprofloxacin) is reported as an ingredient of Ciprofloxacino in the following countries:

• Chile

International Drug Name Search

Broncholate Syrup

Pronunciation: eh-FED-rin/gwye-FEN-ah-sin
Generic Name: Ephedrine/Guaifenesin
Brand Name: Broncholate

Broncholate Syrup is used for:

Relieving congestion, cough, and throat and airway irritation due to colds, flu, or hay fever. It may also be used for other conditions as determined by your doctor.

Broncholate Syrup is a decongestant and expectorant combination. It works by constricting blood vessels, reducing swelling in the nasal passages, and thinning and loosening mucus in the airway. This allows you to breathe more easily and makes coughs more productive.

Do NOT use Broncholate Syrup if:

• you are allergic to any ingredient in Broncholate Syrup


• you have severe high blood pressure, rapid heartbeat, or other severe heart problems (eg, heart blood vessel disease)


• you have taken furazolidone or a monoamine oxidase (MAO) inhibitor (eg, phenelzine) within the last 14 days

Contact your doctor or health care provider right away if any of these apply to you.

Before using Broncholate Syrup:

Some medical conditions may interact with Broncholate Syrup. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

• if you are pregnant, planning to become pregnant, or are breast-feeding


• if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement


• if you have allergies to medicines, foods, or other substances


• if you have a fast, slow, or irregular heartbeat


• if you have a history of adrenal gland problems (eg, tumor), heart problems, high blood pressure, diabetes, heart blood vessel problems, stroke, glaucoma, an enlarged prostate or other prostate problems, seizures, or an overactive thyroid


• if you have chronic cough

Some MEDICINES MAY INTERACT with Broncholate Syrup. Tell your health care provider if you are taking any other medicines, especially any of the following:

• Beta-blockers (eg, propranolol), catechol-O-methyltransferase (COMT) inhibitors (eg, tolcapone), furazolidone, indomethacin, MAO inhibitors (eg, phenelzine), or tricyclic antidepressants (eg, amitriptyline) because the risk of side effects from Broncholate Syrup may be increased


• Digoxin or droxidopa because the risk of irregular heartbeat or heart attack may be increased


• Bromocriptine because the risk of side effects may be increased by Broncholate Syrup


• Guanethidine, guanadrel, mecamylamine, methyldopa, or reserpine because their effectiveness may be decreased by Broncholate Syrup

This may not be a complete list of all interactions that may occur. Ask your health care provider if Broncholate Syrup may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use Broncholate Syrup:

Use Broncholate Syrup as directed by your doctor. Check the label on the medicine for exact dosing instructions. Check the label on the medicine for exact dosing instructions.

• Broncholate Syrup may be taken with or without food.


• Take Broncholate Syrup with a full glass of water unless otherwise directed by your doctor.


• Use a measuring device marked for medicine dosing. Ask your pharmacist for help if you are unsure of how to measure your dose.


• If you miss a dose of Broncholate Syrup, take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once.

Ask your health care provider any questions you may have about how to use Broncholate Syrup.

Important safety information:

• Broncholate Syrup may cause dizziness. Do not drive, operate machinery, or do anything else that could be dangerous until you know how you react to Broncholate Syrup. Using Broncholate Syrup alone, with certain other medicines, or with alcohol may lessen your ability to drive or perform other potentially dangerous tasks.


• Do not take appetite suppressants while you are taking Broncholate Syrup without checking with your doctor.


• Broncholate Syrup contains ephedrine. Before you begin taking any new prescription or nonprescription medicine, read the ingredients to see if it also contains ephedrine. If it does or if you are uncertain, contact your doctor or pharmacist.


• Do NOT exceed the recommended dose or take Broncholate Syrup for longer than prescribed without checking with your doctor.


• If your symptoms do not improve within 5 to 7 days or if they become worse, check with your doctor.


• Broncholate Syrup may interfere with certain lab test results. Make sure that all of your doctors and laboratory personnel know that you are taking Broncholate Syrup.


• Before you have any medical or dental treatments, emergency care, or surgery, tell the doctor or dentist that you are using Broncholate Syrup.


• Use Broncholate Syrup with caution in the ELDERLY because they may be more sensitive to its effects.


• Caution is advised when using Broncholate Syrup in CHILDREN because they may be more sensitive to its effects.


• PREGNANCY and BREAST-FEEDING: If you become pregnant while taking Broncholate Syrup, discuss with your doctor the benefits and risks of using Broncholate Syrup during pregnancy. It is unknown if Broncholate Syrup is excreted in breast milk. Do not breast-feed while taking Broncholate Syrup.

Possible side effects of Broncholate Syrup:

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Dizziness; excitability; headache; nausea; nervousness or anxiety; trouble sleeping; weakness.

Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (rash; hives; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); difficulty urinating; fast or irregular heartbeat; hallucinations; seizures; severe dizziness, lightheadedness, or headache; tremor.

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. To report side effects to the appropriate agency, please read the Guide to Reporting Problems to FDA.

See also: Broncholate side effects (in more detail)

If OVERDOSE is suspected:

Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center, or emergency room immediately. Symptoms may include blurred vision; confusion; hallucinations; seizures; severe dizziness, lightheadedness, or headache; severe drowsiness; unusually fast, slow, or irregular heartbeat; vomiting.

Proper storage of Broncholate Syrup:

Store Broncholate Syrup at room temperature, between 59 and 86 degrees F (15 and 30 degrees C). Store away from heat, moisture, and light. Do not store in the bathroom. Keep Broncholate Syrup out of the reach of children and away from pets.

General information:

• If you have any questions about Broncholate Syrup, please talk with your doctor, pharmacist, or other health care provider.


• Broncholate Syrup is to be used only by the patient for whom it is prescribed. Do not share it with other people.


• If your symptoms do not improve or if they become worse, check with your doctor.


• Check with your pharmacist about how to dispose of unused medicine.

This information is a summary only. It does not contain all information about Broncholate Syrup. If you have questions about the medicine you are taking or would like more information, check with your doctor, pharmacist, or other health care provider.

Issue Date: February 1, 2012

Database Edition 12.1.1.002

Copyright © 2012 Wolters Kluwer Health, Inc.

More Broncholate resources

• Broncholate Side Effects (in more detail)
• Broncholate Use in Pregnancy & Breastfeeding
• Broncholate Drug Interactions
• Broncholate Support Group
• 1 Review for Broncholate - Add your own review/rating

• Primatene Prescribing Information (FDA)

Compare Broncholate with other medications

• Cold Symptoms

brompheniramine, hydrocodone, and pseudoephedrine

Generic Name: brompheniramine, hydrocodone, and pseudoephedrine (brom fen EER a meen, hye droe KOE dohn, soo doe e FED rin)

Brand Names: Anaplex HD, Bromcomp HC, Bromph HD, Bromplex HD, BroveX HC, Drocon-CS, Endacof HC, J-Tan D HC, M-END, SymTan A, Visvex

What is brompheniramine, hydrocodone, and pseudoephedrine?

Brompheniramine is an antihistamine that reduces the natural chemical histamine in the body. Histamine can produce symptoms of sneezing, itching, watery eyes, and runny nose.

Hydrocodone is in a group of drugs called narcotics and is similar to codeine. Hydrocodone is a cough suppressant that affects the signals in the brain that trigger cough reflex.

Pseudoephedrine is a decongestant that shrinks blood vessels in the nasal passages. Dilated blood vessels can cause nasal congestion (stuffy nose).

The combination of brompheniramine, hydrocodone, and pseudoephedrine is used to treat cough, sneezing, itching, watery eyes, runny nose, stuffy nose, and sinus congestion caused by allergies, the common cold, or the flu.

Brompheniramine, hydrocodone, and pseudoephedrine may also be used for other purposes not listed in this medication guide.

What is the most important information I should know about brompheniramine, hydrocodone, and pseudoephedrine?

Always ask a doctor before giving a cough or cold medicine to a child. Death can occur from the misuse of cough and cold medicines in very young children. Do not take this medication with alcohol, other narcotic pain medications, sedatives, tranquilizers, muscle relaxers, or other medicines that can make you sleepy or slow your breathing. Dangerous side effects may result. Hydrocodone may be habit-forming and should be used only by the person it was prescribed for. Hydrocodone should never be shared with another person, especially someone who has a history of drug abuse or addiction. Keep the medication in a secure place where others cannot get to it. Hydrocodone is a drug of abuse and you should be aware if any person in the household is using this medicine improperly or without a prescription. Do not use any other over-the-counter cough, cold, allergy, or sleep medication without first asking your doctor or pharmacist. If you take certain products together you may accidentally take too much of one or more types of medicine. Read the label of any other medicine you are using to see if it contains an antihistamine, decongestant, or cough suppressant. This medication can cause side effects that may impair your thinking or reactions. Be careful if you drive or do anything that requires you to be awake and alert.

What should I discuss with my healthcare provider before taking brompheniramine, hydrocodone, and pseudoephedrine?

Do not use this medication if you are allergic to hydrocodone or other narcotic pain relievers such as fentanyl (Actiq, Duragesic), hydromorphone (Dilaudid, Palladone), methadone (Methadose, Dolophine), morphine (Kadian, MS Contin, Oramorph, and others), oxycodone (OxyContin), and oxymorphone (Opana). Do not use a cough or cold medicine if you have used an MAO inhibitor such as isocarboxazid (Marplan), phenelzine (Nardil), rasagiline (Azilect), selegiline (Eldepryl, Emsam), or tranylcypromine (Parnate) within the past 14 days. Serious, life-threatening side effects can occur if you take cough or cold medicine before the MAO inhibitor has cleared from your body.

Before taking brompheniramine, hydrocodone, and pseudoephedrine, tell your doctor if you are allergic to any drugs, or if you have:

• 
  

  kidney or liver disease;

  
  


• 
  

  heart disease or high blood pressure;

  
  


• 
  

  enlarged prostate or urination problems;

  
  


• 
  

  diabetes;

  
  


• 
  

  glaucoma;

  
  


• 
  

  a thyroid disorder;

  
  


• 
  

  asthma, COPD, sleep apnea, or other breathing disorders;

  
  


• 
  

  a history of head injury or brain tumor;

  
  


• 
  

  epilepsy or other seizure disorder;

  
  


• 
  

  low blood pressure;

  
  


• 
  

  gallbladder disease;

  
  


• 
  

  Addison's disease or other adrenal gland disorders;

  
  


• 
  

  mental illness; or

  
  


• 
  

  a history of drug or alcohol addiction.

  
  

If you have any of these conditions, you may need a dose adjustment or special tests to safely take this medication.

FDA pregnancy category C. Hydrocodone may be harmful to an unborn baby, and could cause addiction or withdrawal symptoms in a newborn. Tell your doctor if you are pregnant or plan to become pregnant during treatment. This medication may pass into breast milk and could harm a nursing baby. Do not use this medication without telling your doctor if you are breast-feeding a baby. Hydrocodone may be habit-forming and should be used only by the person it was prescribed for. Hydrocodone should never be shared with another person, especially someone who has a history of drug abuse or addiction. Keep the medication in a secure place where others cannot get to it. Hydrocodone is a drug of abuse and you should be aware if any person in the household is using this medicine improperly or without a prescription.

How should I take brompheniramine, hydrocodone, and pseudoephedrine?

Take this medication exactly as it was prescribed for you. Do not take the medication in larger amounts, or take it for longer than recommended by your doctor. Follow the directions on your prescription label. Cough or cold medicine is usually taken for only a short time until your symptoms clear up.

Always ask a doctor before giving cough or cold medicine to a child. Death can occur from the misuse of cough or cold medicine in very young children.

Measure the liquid form of this medicine with a special dose-measuring spoon or cup, not a regular table spoon. If you do not have a dose-measuring device, ask your pharmacist for one.

Talk with your doctor if your symptoms do not improve after 7 days of treatment, or if you have a fever with a headache, cough, or skin rash.

If you need to have any type of surgery, tell the surgeon ahead of time if you have taken a cold medicine within the past few days.

This medication can cause you to have unusual results with allergy skin tests. Tell any doctor who treats you that you are taking an antihistamine.

Store this medicine at room temperature, away from heat, light, and moisture.

See also: Brompheniramine, hydrocodone, and pseudoephedrine dosage (in more detail)

What happens if I miss a dose?

Since cough or cold medicine is usually taken only as needed, you may not be on a dosing schedule. If you are taking the medication regularly, take the missed dose as soon as you remember. If it is almost time for your next dose, skip the missed dose and take the medicine at your next regularly scheduled time. Do not take extra medicine to make up the missed dose.

What happens if I overdose?

Seek emergency medical attention if you think you have used too much of this medicine. An overdose of hydrocodone can be fatal. Overdose symptoms may include extreme dizziness or drowsiness, confusion, feeling restless or nervous, cold and clammy skin, warmth or tingly feeling, nausea, vomiting, slow or shallow breathing, slow heart rate, pinpoint pupils, fainting, seizure (convulsions), or coma.

What should I avoid while taking brompheniramine, hydrocodone, and pseudoephedrine?

This medication can cause side effects that may impair your thinking or reactions. Be careful if you drive or do anything that requires you to be awake and alert.

Avoid becoming overheated or dehydrated during exercise and in hot weather.

Do not drink alcohol while you are taking this medication. Alcohol can increase some of the side effects of brompheniramine, hydrocodone, and pseudoephedrine. Do not take this medication with other narcotic pain medications, sedatives, tranquilizers, muscle relaxers, or other medicines that can make you sleepy or slow your breathing. Life-threatening side effects may result.

Avoid taking diet pills, caffeine pills, or other stimulants (such as ADHD medications) without your doctor's advice. Taking a stimulant together with a decongestant can increase your risk of unpleasant side effects.

Do not use any other over-the-counter cough, cold, allergy, or sleep medication without first asking your doctor or pharmacist. Brompheniramine and pseudoephedrine are contained in many medicines available over the counter. If you take certain products together you may accidentally take too much of one or more types of medicine. Read the label of any other medicine you are using to see if it contains brompheniramine or pseudoephedrine.

Brompheniramine, hydrocodone, and pseudoephedrine side effects

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat. Stop using this medication and call your doctor at once if you have any of these serious side effects:

• 
  

  fast, pounding, or uneven heartbeats;

  
  


• 
  

  shallow breathing, slow heartbeat;

  
  


• 
  

  severe dizziness, fainting, anxiety, restless feeling, nervousness, or tremor;

  
  


• 
  

  confusion, hallucinations, unusual thoughts or behavior;

  
  


• 
  

  easy bruising or bleeding, unusual weakness, fever, chills, body aches, flu symptoms;

  
  


• 
  

  urinating less than usual or not at all; or

  
  


• 
  

  increased blood pressure (severe headache, blurred vision, trouble concentrating, chest pain, numbness, seizure).

  
  

Less serious side effects may include:

• 
  

  blurred vision;

  
  


• 
  

  dry mouth;

  
  


• 
  

  nausea, vomiting, stomach pain, constipation, mild loss of appetite;

  
  


• 
  

  mild dizziness, drowsiness;

  
  


• 
  

  problems with memory or concentration;

  
  


• 
  

  ringing in your ears;

  
  


• 
  

  warmth, tingling, or redness under your skin;

  
  


• 
  

  restless or excitability (especially in children);

  
  


• 
  

  sleep problems (insomnia); or

  
  


• 
  

  skin rash or itching.

  
  

This is not a complete list of side effects and others may occur. Tell your doctor about any unusual or bothersome side effect. You may report side effects to FDA at 1-800-FDA-1088.

Brompheniramine, hydrocodone, and pseudoephedrine Dosing Information

Usual Adult Dose for Cough and Nasal Congestion:

Brompheniramine/hydrocodone/pseudoephedrine 2 mg-2.5 mg-15 mg/5 mL oral liquid:
10 mL orally every 4 to 6 hours.

Brompheniramine/hydrocodone/pseudoephedrine 3 mg-2.5 mg-15 mg/5 mL oral liquid:
5 to 10 mL orally every 4 to 6 hours not to exceed 40 mL daily.

Brompheniramine/hydrocodone/pseudoephedrine 6 mg-6 mg-45 mg/5 mL oral suspension, extended release:
5 mL orally every 12 hours not to exceed 10 mL daily.

Usual Pediatric Dose for Cough and Nasal Congestion:

Brompheniramine/hydrocodone/pseudoephedrine 2 mg-2.5 mg-15 mg/5 mL oral liquid:
6 to 11 years: 5 mL orally every 4 to 6 hours.
12 years or older: 10 mL orally every 4 to 6 hours.

Brompheniramine/hydrocodone/pseudoephedrine 3 mg-2.5 mg-15 mg/5 mL oral liquid:
2 to 5 years: 2.5 mL orally every 4 to 6 hours not to exceed 10 mL daily.
6 to 11 years: 5 mL orally every 4 to 6 hours not to exceed 20 mL daily.
12 years or older: 5 to 10 mL orally every 4 to 6 hours not to exceed 40 mL daily

Brompheniramine/hydrocodone/pseudoephedrine 6 mg-6 mg-45 mg/5 mL oral suspension, extended release:
6 to 11 years: 2.5 mL orally every 12 hours not to exceed 5 mL daily.
12 years or older: 5 mL orally every 12 hours not to exceed 10 mL daily.

What other drugs will affect brompheniramine, hydrocodone, and pseudoephedrine?

Before taking this medication, tell your doctor if you are using any of the following drugs:

• 
  

  cimetidine (Tagamet);

  
  


• 
  

  rifampin (Rifadin, Rifater, Rifamate, Rimactane);

  
  


• 
  

  zidovudine (Retrovir, AZT);

  
  


• 
  

  antidepressants such as amitriptyline (Elavil), clomipramine (Anafranil), imipramine (Janimine, Tofranil), and others;

  
  


• 
  

  aspirin or salicylates (such as Disalcid, Doan's Pills, Dolobid, Salflex, Tricosal, and others);

  
  


• 
  

  a beta-blocker such as atenolol (Tenormin), carteolol (Cartrol), metoprolol (Lopressor, Toprol), nadolol (Corgard), propranolol (Inderal), sotalol (Betapace), timolol (Blocadren), and others;

  
  


• 
  

  bladder or urinary medications such as oxybutynin (Ditropan, Oxytrol) or tolterodine (Detrol);

  
  


• 
  

  a diuretic (water pill), or blood pressure medication;

  
  


• 
  

  medication to treat irritable bowel syndrome;

  
  


• 
  

  medicines to treat psychiatric disorders, such as chlorpromazine (Thorazine), haloperidol (Haldol), mesoridazine (Serentil), pimozide (Orap), or thioridazine (Mellaril); or

  
  


• 
  

  seizure medication such as phenytoin (Dilantin) or phenobarbital (Luminal, Solfoton).

  
  

This list is not complete and there may be other drugs that can interact with brompheniramine, hydrocodone, and pseudoephedrine. Tell your doctor about all the prescription and over-the-counter medications you use. This includes vitamins, minerals, herbal products, and drugs prescribed by other doctors. Do not start using a new medication without telling your doctor.

More brompheniramine, hydrocodone, and pseudoephedrine resources

• Brompheniramine, hydrocodone, and pseudoephedrine Side Effects (in more detail)
• Brompheniramine, hydrocodone, and pseudoephedrine Dosage
• Brompheniramine, hydrocodone, and pseudoephedrine Use in Pregnancy & Breastfeeding
• Brompheniramine, hydrocodone, and pseudoephedrine Drug Interactions
• Brompheniramine, hydrocodone, and pseudoephedrine Support Group
• 0 Reviews for Brompheniramine, hydrocodone, and pseudoephedrine - Add your own review/rating

Compare brompheniramine, hydrocodone, and pseudoephedrine with other medications

• Cough and Nasal Congestion

Where can I get more information?

• Your pharmacist can provide more information about brompheniramine, hydrocodone, and pseudoephedrine.

See also: brompheniramine, hydrocodone, and pseudoephedrine side effects (in more detail)

Blephamide Suspension

Pronunciation: pred-NISS-oh-lone/sul-fa-SEE-ta-mide
Generic Name: Prednisolone/Sulfacetamide
Brand Name: Blephamide

Blephamide Suspension is used for:

Treating inflammation (swelling, warmth, redness, pain) of the eyes and eyelids when infection or risk of infection is present.

Blephamide Suspension is an antibacterial and corticosteroid combination. It works by reducing the itching, redness, and swelling of the eye. It also works to stop the growth of certain bacteria that cause eye infections.

Do NOT use Blephamide Suspension if:

• you are allergic to any ingredient in Blephamide Suspension, to other corticosteroids (eg, dexamethasone), or to other sulfonamides (eg, acetazolamide, celecoxib, hydrochlorothiazide, glyburide, probenecid, sulfamethoxazole, valdecoxib, zonisamide)


• you have a viral eye infection (eg, herpes simplex, vaccinia, chickenpox), tuberculosis eye infection, or fungal infection of the eye or eye structures


• you have thinning of the cornea of the eye

Contact your doctor or health care provider right away if any of these apply to you.

Before using Blephamide Suspension:

Some medical conditions may interact with Blephamide Suspension. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

• if you are pregnant, planning to become pregnant, or are breast-feeding


• if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement


• if you have allergies to medicines, foods, or other substances


• if you have thinning of the eye tissues (eg, cornea, sclera), other eye problems (eg, glaucoma, cataracts, nerve damage), severe dry eyes, or diabetes


• if you have recently had cataract surgery

Some MEDICINES MAY INTERACT with Blephamide Suspension. Tell your health care provider if you are taking any other medicine, especially any of the following:

• Silver-containing medicines (eg, silver nitrate) because the risk of side effects may be increased

This may not be a complete list of all interactions that may occur. Ask your health care provider if Blephamide Suspension may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use Blephamide Suspension:

Use Blephamide Suspension as directed by your doctor. Check the label on the medicine for exact dosing instructions.

• Shake well before each use.


• To use Blephamide Suspension in the eye, first, wash your hands. Tilt your head back. Using your index finger, pull the lower eyelid away from the eye to form a pouch. Drop the medicine into the pouch and gently close your eyes. Immediately use your finger to apply pressure to the inside corner of the eyelid for 1 to 2 minutes. Do not blink. Remove excess medicine around your eye with a clean, dry tissue, being careful not to touch your eye. Wash your hands to remove any medicine that may be on them.


• To prevent germs from contaminating your medicine, do not touch the applicator tip to any surface, including the eye. Keep the container tightly closed.


• To clear up your infection completely, use Blephamide Suspension for the full course of treatment. Keep using it even if you feel better in a few days.


• Do not use Blephamide Suspension if it is dark brown or has darkened since you began using it. Contact your doctor or pharmacist if you have questions about whether you should use Blephamide Suspension.


• Do not wear contact lenses while you are using Blephamide Suspension. Take care of your contact lenses as directed by the manufacturer. Check with your doctor before you use them.


• If you miss a dose of Blephamide Suspension, use it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not use 2 doses at once.

Ask your health care provider any questions you may have about how to use Blephamide Suspension.

Important safety information:

• Blephamide Suspension may cause blurred vision. These effects may be worse if you take it with alcohol or certain medicines. Use Blephamide Suspension with caution. Do not drive or perform other possibly unsafe tasks until you know how you react to it.


• If your symptoms do not get better within 2 days or if they get worse, check with your doctor.


• Be sure to use Blephamide Suspension for the full course of treatment. If you do not, the medicine may not clear up your infection completely. The bacteria could also become less sensitive to this or other medicines. This could make the infection harder to treat in the future.


• Long-term or repeated use of Blephamide Suspension may cause a second infection. Tell your doctor if signs of a second infection occur. Your medicine may need to be changed to treat this.


• Tell your doctor or dentist that you take Blephamide Suspension before you receive any medical or dental care, emergency care, or surgery.


• Do not use Blephamide Suspension for future eye problems unless directed by your doctor.


• Lab tests, including eye pressure, may be performed while you use Blephamide Suspension. These tests may be used to monitor your condition or check for side effects. Be sure to keep all doctor and lab appointments.


• Blephamide Suspension should be used with extreme caution in CHILDREN younger than 6 years old; safety and effectiveness in these children have not been confirmed.


• PREGNANCY and BREAST-FEEDING: If you become pregnant, contact your doctor. You will need to discuss the benefits and risks of using Blephamide Suspension while you are pregnant. It is not known if Blephamide Suspension is found in breast milk. Do not breast-feed while using Blephamide Suspension.

Possible side effects of Blephamide Suspension:

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Temporary burning or stinging.

Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); changes in vision; eye pain, itching, redness, swelling, irritation, or sores not present when you began using Blephamide Suspension; fever, chills, or sore throat; red, swollen, or blistered skin; severe or persistent blurred vision; unusual tiredness or weakness; yellowing of the eyes or skin

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. To report side effects to the appropriate agency, please read the Guide to Reporting Problems to FDA.

See also: Blephamide side effects (in more detail)

If OVERDOSE is suspected:

Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center, or emergency room immediately.

Proper storage of Blephamide Suspension:

Store Blephamide Suspension at room temperature, between 59 and 77 degrees F (15 and 25 degrees C). Do not freeze. Store away from heat and light. Keep Blephamide Suspension out of the reach of children and away from pets.

General information:

• If you have any questions about Blephamide Suspension, please talk with your doctor, pharmacist, or other health care provider.


• Blephamide Suspension is to be used only by the patient for whom it is prescribed. Do not share it with other people.


• If your symptoms do not improve or if they become worse, check with your doctor.


• Check with your pharmacist about how to dispose of unused medicine.

This information is a summary only. It does not contain all information about Blephamide Suspension. If you have questions about the medicine you are taking or would like more information, check with your doctor, pharmacist, or other health care provider.

Issue Date: February 1, 2012

Database Edition 12.1.1.002

Copyright © 2012 Wolters Kluwer Health, Inc.

More Blephamide resources

• Blephamide Side Effects (in more detail)
• Blephamide Use in Pregnancy & Breastfeeding
• Blephamide Drug Interactions
• Blephamide Support Group
• 1 Review for Blephamide - Add your own review/rating

Compare Blephamide with other medications

• Blepharitis
• Conjunctivitis, Bacterial
• Keratitis
• Keratoconjunctivitis
• Uveitis

Bromplex HD

Generic Name: brompheniramine, hydrocodone, and pseudoephedrine (brom fen EER a meen, hye droe KOE dohn, soo doe e FED rin)

Brand Names: Anaplex HD, Bromcomp HC, Bromph HD, Bromplex HD, BroveX HC, Drocon-CS, Endacof HC, J-Tan D HC, M-END, SymTan A, Visvex

What is Bromplex HD (brompheniramine, hydrocodone, and pseudoephedrine)?

Brompheniramine is an antihistamine that reduces the natural chemical histamine in the body. Histamine can produce symptoms of sneezing, itching, watery eyes, and runny nose.

Hydrocodone is in a group of drugs called narcotics and is similar to codeine. Hydrocodone is a cough suppressant that affects the signals in the brain that trigger cough reflex.

Pseudoephedrine is a decongestant that shrinks blood vessels in the nasal passages. Dilated blood vessels can cause nasal congestion (stuffy nose).

The combination of brompheniramine, hydrocodone, and pseudoephedrine is used to treat cough, sneezing, itching, watery eyes, runny nose, stuffy nose, and sinus congestion caused by allergies, the common cold, or the flu.

Brompheniramine, hydrocodone, and pseudoephedrine may also be used for other purposes not listed in this medication guide.

What is the most important information I should know about Bromplex HD (brompheniramine, hydrocodone, and pseudoephedrine)?

Always ask a doctor before giving a cough or cold medicine to a child. Death can occur from the misuse of cough and cold medicines in very young children. Do not take this medication with alcohol, other narcotic pain medications, sedatives, tranquilizers, muscle relaxers, or other medicines that can make you sleepy or slow your breathing. Dangerous side effects may result. Hydrocodone may be habit-forming and should be used only by the person it was prescribed for. Hydrocodone should never be shared with another person, especially someone who has a history of drug abuse or addiction. Keep the medication in a secure place where others cannot get to it. Hydrocodone is a drug of abuse and you should be aware if any person in the household is using this medicine improperly or without a prescription. Do not use any other over-the-counter cough, cold, allergy, or sleep medication without first asking your doctor or pharmacist. If you take certain products together you may accidentally take too much of one or more types of medicine. Read the label of any other medicine you are using to see if it contains an antihistamine, decongestant, or cough suppressant. This medication can cause side effects that may impair your thinking or reactions. Be careful if you drive or do anything that requires you to be awake and alert.

What should I discuss with my healthcare provider before taking Bromplex HD (brompheniramine, hydrocodone, and pseudoephedrine)?

Do not use this medication if you are allergic to hydrocodone or other narcotic pain relievers such as fentanyl (Actiq, Duragesic), hydromorphone (Dilaudid, Palladone), methadone (Methadose, Dolophine), morphine (Kadian, MS Contin, Oramorph, and others), oxycodone (OxyContin), and oxymorphone (Opana). Do not use a cough or cold medicine if you have used an MAO inhibitor such as isocarboxazid (Marplan), phenelzine (Nardil), rasagiline (Azilect), selegiline (Eldepryl, Emsam), or tranylcypromine (Parnate) within the past 14 days. Serious, life-threatening side effects can occur if you take cough or cold medicine before the MAO inhibitor has cleared from your body.

Before taking brompheniramine, hydrocodone, and pseudoephedrine, tell your doctor if you are allergic to any drugs, or if you have:

• 
  

  kidney or liver disease;

  
  


• 
  

  heart disease or high blood pressure;

  
  


• 
  

  enlarged prostate or urination problems;

  
  


• 
  

  diabetes;

  
  


• 
  

  glaucoma;

  
  


• 
  

  a thyroid disorder;

  
  


• 
  

  asthma, COPD, sleep apnea, or other breathing disorders;

  
  


• 
  

  a history of head injury or brain tumor;

  
  


• 
  

  epilepsy or other seizure disorder;

  
  


• 
  

  low blood pressure;

  
  


• 
  

  gallbladder disease;

  
  


• 
  

  Addison's disease or other adrenal gland disorders;

  
  


• 
  

  mental illness; or

  
  


• 
  

  a history of drug or alcohol addiction.

  
  

If you have any of these conditions, you may need a dose adjustment or special tests to safely take this medication.

FDA pregnancy category C. Hydrocodone may be harmful to an unborn baby, and could cause addiction or withdrawal symptoms in a newborn. Tell your doctor if you are pregnant or plan to become pregnant during treatment. This medication may pass into breast milk and could harm a nursing baby. Do not use this medication without telling your doctor if you are breast-feeding a baby. Hydrocodone may be habit-forming and should be used only by the person it was prescribed for. Hydrocodone should never be shared with another person, especially someone who has a history of drug abuse or addiction. Keep the medication in a secure place where others cannot get to it. Hydrocodone is a drug of abuse and you should be aware if any person in the household is using this medicine improperly or without a prescription.

How should I take Bromplex HD (brompheniramine, hydrocodone, and pseudoephedrine)?

Take this medication exactly as it was prescribed for you. Do not take the medication in larger amounts, or take it for longer than recommended by your doctor. Follow the directions on your prescription label. Cough or cold medicine is usually taken for only a short time until your symptoms clear up.

Always ask a doctor before giving cough or cold medicine to a child. Death can occur from the misuse of cough or cold medicine in very young children.

Measure the liquid form of this medicine with a special dose-measuring spoon or cup, not a regular table spoon. If you do not have a dose-measuring device, ask your pharmacist for one.

Talk with your doctor if your symptoms do not improve after 7 days of treatment, or if you have a fever with a headache, cough, or skin rash.

If you need to have any type of surgery, tell the surgeon ahead of time if you have taken a cold medicine within the past few days.

This medication can cause you to have unusual results with allergy skin tests. Tell any doctor who treats you that you are taking an antihistamine.

Store this medicine at room temperature, away from heat, light, and moisture.

What happens if I miss a dose?

Since cough or cold medicine is usually taken only as needed, you may not be on a dosing schedule. If you are taking the medication regularly, take the missed dose as soon as you remember. If it is almost time for your next dose, skip the missed dose and take the medicine at your next regularly scheduled time. Do not take extra medicine to make up the missed dose.

What happens if I overdose?

Seek emergency medical attention if you think you have used too much of this medicine. An overdose of hydrocodone can be fatal. Overdose symptoms may include extreme dizziness or drowsiness, confusion, feeling restless or nervous, cold and clammy skin, warmth or tingly feeling, nausea, vomiting, slow or shallow breathing, slow heart rate, pinpoint pupils, fainting, seizure (convulsions), or coma.

What should I avoid while taking Bromplex HD (brompheniramine, hydrocodone, and pseudoephedrine)?

This medication can cause side effects that may impair your thinking or reactions. Be careful if you drive or do anything that requires you to be awake and alert.

Avoid becoming overheated or dehydrated during exercise and in hot weather.

Do not drink alcohol while you are taking this medication. Alcohol can increase some of the side effects of brompheniramine, hydrocodone, and pseudoephedrine. Do not take this medication with other narcotic pain medications, sedatives, tranquilizers, muscle relaxers, or other medicines that can make you sleepy or slow your breathing. Life-threatening side effects may result.

Avoid taking diet pills, caffeine pills, or other stimulants (such as ADHD medications) without your doctor's advice. Taking a stimulant together with a decongestant can increase your risk of unpleasant side effects.

Do not use any other over-the-counter cough, cold, allergy, or sleep medication without first asking your doctor or pharmacist. Brompheniramine and pseudoephedrine are contained in many medicines available over the counter. If you take certain products together you may accidentally take too much of one or more types of medicine. Read the label of any other medicine you are using to see if it contains brompheniramine or pseudoephedrine.

Bromplex HD (brompheniramine, hydrocodone, and pseudoephedrine) side effects

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat. Stop using this medication and call your doctor at once if you have any of these serious side effects:

• 
  

  fast, pounding, or uneven heartbeats;

  
  


• 
  

  shallow breathing, slow heartbeat;

  
  


• 
  

  severe dizziness, fainting, anxiety, restless feeling, nervousness, or tremor;

  
  


• 
  

  confusion, hallucinations, unusual thoughts or behavior;

  
  


• 
  

  easy bruising or bleeding, unusual weakness, fever, chills, body aches, flu symptoms;

  
  


• 
  

  urinating less than usual or not at all; or

  
  


• 
  

  increased blood pressure (severe headache, blurred vision, trouble concentrating, chest pain, numbness, seizure).

  
  

Less serious side effects may include:

• 
  

  blurred vision;

  
  


• 
  

  dry mouth;

  
  


• 
  

  nausea, vomiting, stomach pain, constipation, mild loss of appetite;

  
  


• 
  

  mild dizziness, drowsiness;

  
  


• 
  

  problems with memory or concentration;

  
  


• 
  

  ringing in your ears;

  
  


• 
  

  warmth, tingling, or redness under your skin;

  
  


• 
  

  restless or excitability (especially in children);

  
  


• 
  

  sleep problems (insomnia); or

  
  


• 
  

  skin rash or itching.

  
  

This is not a complete list of side effects and others may occur. Tell your doctor about any unusual or bothersome side effect. You may report side effects to FDA at 1-800-FDA-1088.

What other drugs will affect Bromplex HD (brompheniramine, hydrocodone, and pseudoephedrine)?

Before taking this medication, tell your doctor if you are using any of the following drugs:

• 
  

  cimetidine (Tagamet);

  
  


• 
  

  rifampin (Rifadin, Rifater, Rifamate, Rimactane);

  
  


• 
  

  zidovudine (Retrovir, AZT);

  
  


• 
  

  antidepressants such as amitriptyline (Elavil), clomipramine (Anafranil), imipramine (Janimine, Tofranil), and others;

  
  


• 
  

  aspirin or salicylates (such as Disalcid, Doan's Pills, Dolobid, Salflex, Tricosal, and others);

  
  


• 
  

  a beta-blocker such as atenolol (Tenormin), carteolol (Cartrol), metoprolol (Lopressor, Toprol), nadolol (Corgard), propranolol (Inderal), sotalol (Betapace), timolol (Blocadren), and others;

  
  


• 
  

  bladder or urinary medications such as oxybutynin (Ditropan, Oxytrol) or tolterodine (Detrol);

  
  


• 
  

  a diuretic (water pill), or blood pressure medication;

  
  


• 
  

  medication to treat irritable bowel syndrome;

  
  


• 
  

  medicines to treat psychiatric disorders, such as chlorpromazine (Thorazine), haloperidol (Haldol), mesoridazine (Serentil), pimozide (Orap), or thioridazine (Mellaril); or

  
  


• 
  

  seizure medication such as phenytoin (Dilantin) or phenobarbital (Luminal, Solfoton).

  
  

This list is not complete and there may be other drugs that can interact with brompheniramine, hydrocodone, and pseudoephedrine. Tell your doctor about all the prescription and over-the-counter medications you use. This includes vitamins, minerals, herbal products, and drugs prescribed by other doctors. Do not start using a new medication without telling your doctor.

More Bromplex HD resources

• Bromplex HD Use in Pregnancy & Breastfeeding
• Bromplex HD Drug Interactions
• Bromplex HD Support Group
• 0 Reviews for Bromplex HD - Add your own review/rating

• Brompheniramine/Hydrocodone/Pseudoephedrine Liquid MedFacts Consumer Leaflet (Wolters Kluwer)


• SymTan A Suspension MedFacts Consumer Leaflet (Wolters Kluwer)

Compare Bromplex HD with other medications

• Cough and Nasal Congestion

Where can I get more information?

• Your pharmacist can provide more information about brompheniramine, hydrocodone, and pseudoephedrine.